Broward Sheriff Fire Rescue responded to the scene of the crash in the southbound lanes of Interstate 75, along Mile Marker 38.
Officials said there were 12 passengers in the van. Nine of them sustained injuries.
Paramedics transported six of the victims to Cleveland Clinic for treatment. Their injuries were not serious.
Officials said all passengers had their seat belts on at the time of the accident.
The cause of this crash remains unclear.