A novel therapeutic strategy for treating inflammatory bowel diseases (IBD) would work by removing inflammation-inducing succinate molecules secreted by gut bacteria.
The method is based on findings in the biochemistry and pharmacology lab of Ben-Gurion University of the Negev professor Ehud Ohana showing increased gut levels of succinate in people with IBD.
Succinate is a metabolic molecule involved in various biochemical cell processes. Several recent studies show that succinate drives inflammation, in particular the inflammatory activity of macrophages, white blood cells in the immune system.
Isolating the succinate molecules and chelating them — a chemical bonding process that helps remove them from the body — is proposed in a study conducted by Moran Fremder, an MD/PhD student in Ohana’s lab, in collaboration with professor Jae Hee Cheon from Yonsei University in South Korea.
IBD, primarily Crohn’s disease and ulcerative colitis, affect up to 1.5 percent of U.S. adults and millions of people globally and can lead to a severely impaired quality of life and to significant morbidity.
“Current treatments for IBD include antibiotics, steroids and biological treatments aimed at inhibiting the activity of the immune system. Such treatments can have long-term side effects, and none address the root causes underlying IBD, which are largely unknown,” said Ohana.
“Our novel findings show that IBD is driven, at least partially, by changes in the activity of gut bacteria and by the accumulation of succinate in the gut, leading to chronic inflammation. Therefore, chelation of succinate can treat IBD and reduce inflammation.”
Ohana said his lab’s therapeutic peptides “are identical to molecules that naturally exist in our body and are therefore unlikely to provoke a harmful immune reaction.”
The researchers also propose using biochemical methods to measure succinate concentrations in biological specimens for better diagnosis and monitoring of IBD and related symptoms.
The findings of the study were published in Cell Reports.
Josh Peleg, CEO of the university’s tech-transfer company, BGN Technologies, said BGN has filed for patent protection and now seeks a strategic partner for the further developing and commercializing this promising invention.
Novel Biological Treatment For Inflammatory Bowel Diseases appeared first on Israel21C.
Edited by Judith Isacoff and Kristen Butler
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