Understanding Lp(a): A Threat to Heart Health

Lp(a), a lesser known but significant risk factor for heart disease. Lp(a), is a sticky protein that raises heart disease risk. Here’s a breakdown:

What is Lp(a)? It’s a protein particle in the blood that carries cholesterol and fats. Unlike other cholesterol levels, diet and lifestyle and exercise don’t affect Lp(a). It’s determined by genes and remains fairly constant throughout life.

The Problem with High Lp(a): Elevated Lp(a) levels are sticky and can build up in blood vessels, narrowing them (atherosclerosis). This increases the risk of blood clots, potentially leading to heart attacks, strokes, and other cardiovascular issues.

Who is Affected? Around 1 in 5 people globally have elevated Lp(a), with a higher prevalence among African Americans and South Asians. Women may also see increased levels after menopause.

Diagnosis and Management: Most standard cholesterol tests don’t screen for Lp(a). However, a simple blood test can check its levels. While current medications don’t directly lower Lp(a), managing other risk factors like blood pressure, cholesterol, and maintaining a healthy lifestyle is crucial.

Hope on the Horizon: New treatment options, including gene silencing therapy, are being investigated to potentially reduce Lp(a) levels and provide future hope for those with elevated levels.

Living with Elevated Lp(a):

Increased Risk: People with high Lp(a) face a 2-4 times greater risk of developing heart disease compared to those with normal levels.

Importance of Early Detection: Family history of cardiovascular disease or a known case of elevated Lp(a) in a close relative warrants testing. Early detection allows for better management of risk factors.

Emotional Impact: A diagnosis can lead to anxiety and vulnerability. Talking to a healthcare professional can help manage mental well-being.

The Future of Lp(a): Research into new therapies offers promise for lowering Lp(a) levels and potentially reducing the cardiovascular risk associated with it.

Testing for Elevated Lp(a)

Standard cholesterol tests often don’t include Lp(a) screening.

Discuss testing with your doctor if you’re at risk.

Remember, knowledge is power! Talk to your doctor about Lp(a) and see if testing is right for you. By working together, we can keep your heart happy and healthy!

Complete article: https://silence-therapeutics.com/patients/cardiovascular-disease-with-high-lipoproteina/making-sense-of-lpa/default.aspx